SCHEMBL2665296 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	GCK	P35557	15/20	0.48

▸	KCNH2	Q12809	2/20	0.41

▸	NPC1	O15118	1/20	0.30

▸	TP53	P04637	1/20	0.30

▸	CYP1A2	P05177	1/20	0.30

▸	CYP3A4	P08684	1/20	0.30

▸	CYP2D6	P10635	1/20	0.30

▸	ALOX15	P16050	1/20	0.30

▸	CYP2C19	P33261	1/20	0.30

▸	RAB9A	P51151	1/20	0.30

▸	SMN1; SMN2	Q16637	1/20	0.30

▸	PDE4B	Q07343	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2665262	0.91	GCK (0.48)	GCKKCNH2
SCHEMBL2665280	0.90	GCK (0.47)	GCKKCNH2
SCHEMBL2665275	0.90	GCK (0.47)	GCKKCNH2
SCHEMBL9072573	0.89	GCK (0.47)	GCKKCNH2
SCHEMBL2665294	0.88	GCK (0.46)	GCKKCNH2
SCHEMBL9072556	0.88	GCK (0.46)	GCKKCNH2
SCHEMBL2665323	0.88	GCK (0.46)	GCKKCNH2
SCHEMBL2665245	0.88	GCK (0.48)	GCKKCNH2
SCHEMBL2665285	0.87	GCK (0.47)	GCKKCNH2
SCHEMBL2665306	0.87	GCK (0.45)	GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-7132425-B2	5-substituted-six-membered heteroaromatic glucokinase activators	HOFFMANN-LA ROCHE INC. (US)	2006-11-07	—	—	US	disclosed