Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 9/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2665311 | 0.93 | GCK (0.46) | GCKKCNH2EPHX2 | |
| SCHEMBL2665245 | 0.89 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2665296 | 0.87 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2665312 | 0.87 | GCK (0.44) | GCKKCNH2 | |
| SCHEMBL2665276 | 0.87 | KCNH2 (0.45) | GCKKCNH2 | |
| SCHEMBL2665316 | 0.86 | GCK (0.45) | GCKKCNH2 | |
| SCHEMBL2665279 | 0.85 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2665262 | 0.84 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2665273 | 0.84 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2665292 | 0.83 | GCK (0.46) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132425-B2 | 5-substituted-six-membered heteroaromatic glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2006-11-07 | — | — | US | disclosed |