Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 7/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2665265 | 0.91 | GCK (0.46) | GCKKCNH2 | |
| SCHEMBL9072578 | 0.83 | KCNH2 (0.52) | GCKKCNH2ALDH1A1 | |
| SCHEMBL9072563 | 0.83 | GCK (0.40) | GCKKCNH2ALDH1A1 | |
| SCHEMBL9072610 | 0.79 | GCK (0.47) | GCKKCNH2 | |
| SCHEMBL2665335 | 0.79 | GCK (0.44) | GCKKCNH2CYP1A2ALOX5AP | |
| SCHEMBL9072614 | 0.79 | GCK (0.45) | GCKKCNH2 | |
| SCHEMBL2665299 | 0.79 | GCK (0.44) | GCKKCNH2ALDH1A1 | |
| SCHEMBL2665292 | 0.78 | GCK (0.46) | GCKKCNH2ALDH1A1CYP1A2ALOX5AP | |
| SCHEMBL2665262 | 0.77 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2665312 | 0.77 | GCK (0.44) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132425-B2 | 5-substituted-six-membered heteroaromatic glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2006-11-07 | — | — | US | disclosed |