Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 6/20 | 0.44 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9072572 | 0.91 | GCK (0.43) | GCKMAPK1KCNH2 | |
| SCHEMBL2665295 | 0.88 | GCK (0.57) | GCKKCNH2 | |
| SCHEMBL9072563 | 0.81 | GCK (0.40) | GCKHTRA1KCNH2ALDH1A1 | |
| SCHEMBL2665332 | 0.79 | GCK (0.36) | GCKKCNH2ALDH1A1 | |
| SCHEMBL9072578 | 0.79 | KCNH2 (0.52) | GCKKCNH2ALDH1A1 | |
| SCHEMBL2665284 | 0.77 | GCK (0.42) | GCKMAPK1KCNH2 | |
| SCHEMBL2665279 | 0.74 | GCK (0.48) | GCKKCNH2 | |
| SCHEMBL2665274 | 0.74 | GCK (0.44) | GCKMAPK1KCNH2 | |
| SCHEMBL2665268 | 0.74 | GCK (0.44) | GCKKCNH2 | |
| SCHEMBL2665327 | 0.73 | GCK (0.46) | GCKKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132425-B2 | 5-substituted-six-membered heteroaromatic glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2006-11-07 | — | — | US | disclosed |