SCHEMBL2665378

SCHEMBL2665378

O=C(Nc1nn[nH]n1)c1ccc(CN(/C(=N\CC(F)(F)F)Nc2cc(Br)cc(C(F)(F)F)c2)c2ccc(C3CCCCC3)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GCGR P47871 20/20 0.47
GIPR P48546 12/20 0.45
GCG P01275 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2665457 0.93 GCGR (0.47) GCGRGIPRGCG
SCHEMBL2663212 0.90 GCGR (0.54) GCGRGIPRGCG
SCHEMBL9071007 0.89 GCGR (0.50) GCGRGIPRGCG
SCHEMBL9070983 0.89 GCGR (0.51) GCGRGIPRGCG
SCHEMBL2665442 0.89 GCGR (0.50) GCGRGIPRGCG
SCHEMBL2665383 0.88 GCGR (0.56) GCGRGIPRGCG
SCHEMBL2665412 0.85 GCGR (0.47) GCGRGIPRGCG
SCHEMBL4091259 0.85 GCGR (0.58) GCGRGIPRGCG
SCHEMBL13799980 0.84 GCGR (0.51) GCGRGIPRGCG
SCHEMBL9070989 0.84 GCGR (0.54) GCGRGIPRGCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003051357-A1 GLUCAGON RECEPTOR ANTAGONISTS/INVERSE AGONISTS NOVO NORDISK A/S (DK) 2003-06-26 WO disclosed