Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.55 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.55 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 3/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30658025 | 0.81 | SMARCA2 (0.55) | SMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL26654066 | 0.81 | SMARCA2 (0.55) | SMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL30658008 | 0.81 | SYK (0.38) | JAK2JAK1SYKCCR5ATM | |
| SCHEMBL26653999 | 0.81 | SYK (0.38) | JAK2JAK1SYKCCR5ATM | |
| SCHEMBL26654087 | 0.80 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1TERTOPRD1 | |
| SCHEMBL26653892 | 0.78 | SMARCA2 (0.43) | SMARCA2SMARCA4PBRM1TSHRALOX15 | |
| SCHEMBL26653917 | 0.74 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL26654143 | 0.74 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1OPRD1GPR119 | |
| SCHEMBL21421698 | 0.73 | PBRM1 (0.83) | SMARCA2SMARCA4PBRM1CYP11B2 | |
| SCHEMBL30666248 | 0.73 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250302832-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-10-02 | — | — | US | disclosed |
| EP-4522279-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250302832-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | BRCA1, VHL, SF3B5 | SMARCA2 77/4885SMARCA4 19/4885PBRM1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.