Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 15/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 14/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 14/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30658026 | 0.86 | SMARCA2 (0.50) | PBRM1SMARCA2SMARCA4BRD4 | |
| SCHEMBL26653951 | 0.82 | PBRM1 (0.38) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30658005 | 0.82 | PBRM1 (0.38) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL26801645 | 0.82 | PBRM1 (0.38) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL26654217 | 0.78 | DYRK1A (0.31) | — | |
| SCHEMBL26653887 | 0.72 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL26653880 | 0.72 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL26653899 | 0.72 | PBRM1 (0.37) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30658035 | 0.66 | SMARCA2 (0.47) | PBRM1SMARCA2SMARCA4NR1I2PDE10A | |
| SCHEMBL30658036 | 0.65 | SSTR4 (0.39) | BRD4NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |