Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931073 | 0.84 | ALDH1A1 (0.53) | MAPTALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL31750473 | 0.84 | ALDH1A1 (0.53) | MAPTALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL18342728 | 0.80 | MEN1 (0.43) | MAPTALDH1A1MAPK1NPC1RAB9A | |
| SCHEMBL20693046 | 0.78 | KMT2A (0.37) | MAPTALDH1A1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL26768026 | 0.78 | CHEK1 (0.42) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL25344403 | 0.77 | ALDH1A1 (0.46) | MAPTALDH1A1MAPK1SMN1; SMN2ATM | |
| SCHEMBL1712168 | 0.77 | TDP1 (0.42) | MAPTALDH1A1AKR1C3AKR1C2MAPK1 | |
| SCHEMBL16858599 | 0.76 | MAPT (0.39) | MAPTALDH1A1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL25358104 | 0.76 | MAPT (0.37) | MAPTALDH1A1MAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL29650091 | 0.75 | ALDH1A1 (0.61) | MAPTTHRBALDH1A1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4524139-A1 | IMIDAZOPYRIDAZINE SUBSTITUTED BENZENE RING DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2025-03-19 | — | — | EP | disclosed |
| CN-117069725-A | Imidazopyridazine substituted benzene ring derivative, preparation method, pharmaceutical composition and application | 上海赛默罗生物科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2023216753-A1 | IMIDAZOPYRIDAZINE SUBSTITUTED BENZENE RING DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | 上海赛默罗生物科技有限公司 | 2023-11-16 | — | — | WO | disclosed |