Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26657035 | 0.94 | GRM4 (0.46) | GRM4AVPR2GPR27IDH1HTT | |
| SCHEMBL26666290 | 0.93 | GRM4 (0.46) | GRM4AVPR2GPR27MEN1KMT2A | |
| SCHEMBL26657094 | 0.91 | IDH1 (0.49) | GRM4IDH1HTR2AHTR2C | |
| SCHEMBL26662228 | 0.89 | GRM4 (0.43) | GRM4AVPR2GPR27IDH1HTT | |
| SCHEMBL26656788 | 0.89 | NPC1 (0.47) | GRM4AVPR2GPR27IDH1HTT | |
| SCHEMBL26657265 | 0.89 | SMN1; SMN2 (0.50) | GRM4MEN1KMT2AIDH1HTT | |
| SCHEMBL26658173 | 0.89 | GRM4 (0.46) | GRM4MEN1KMT2AHTTFLT1 | |
| SCHEMBL26658115 | 0.88 | FLT1 (0.45) | GRM4MEN1KMT2AHTTFLT1 | |
| SCHEMBL26657039 | 0.87 | NPC1 (0.61) | GRM4IDH1HTTNPC1RAB9A | |
| SCHEMBL26665093 | 0.87 | GRM4 (0.47) | GRM4IDH1HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339851-A1 | CXCR6 SULFONAMIDE COMPOUNDS | CHEMOCENTRYX, INC. | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339851-A1 | CXCR6 SULFONAMIDE COMPOUNDS | CXCR6, CXCR1, CXCR2 | GRM4 768/4885AVPR2 62/4885GPR27 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.