Sugi Predict

Sugi Predict / Targets / CXCR6

CXCR6

C-X-C chemokine receptor type 6 · O00574 · CXCR6 on Sugi Atlas →

1,845 patent compounds predicted against CXCR6, 1,073 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL9021741 SCHEMBL9021741 0.53 17/20
SCHEMBL6889532 SCHEMBL6889532 0.57 13/20
SCHEMBL3415947 SCHEMBL3415947 0.85 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL2114038) 0.83 11/20
SCHEMBL9021398 SCHEMBL9021398 0.47 11/20
SCHEMBL1786435 SCHEMBL1786435 0.63 9/20
SCHEMBL3213873 SCHEMBL3213873 0.44 9/20
SCHEMBL9021379 SCHEMBL9021379 0.53 8/20
SCHEMBL6463274 SCHEMBL6463274 0.50 7/20
SCHEMBL6463284 SCHEMBL6463284 0.50 7/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL3226942) 0.48 7/20
SCHEMBL6871762 SCHEMBL6871762 0.47 7/20
SCHEMBL6871766 SCHEMBL6871766 0.47 7/20
SCHEMBL1902477 SCHEMBL1902477 0.49 6/20
Trifluoroacetic Acid Trifluoroacetic Acid (SCHEMBL3215410) 0.48 6/20
SCHEMBL6886856 SCHEMBL6886856 0.46 6/20
SCHEMBL1224281 SCHEMBL1224281 0.45 6/20
SCHEMBL11166945 SCHEMBL11166945 0.69 5/20
SCHEMBL3478681 SCHEMBL3478681 0.64 5/20
SCHEMBL11167422 SCHEMBL11167422 0.62 5/20

Clinical trials — most relevant to CXCR6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy of Ibuprofen Chronotherapy in Healing After Surgical Extraction of the Mandibular Third Molar PHASE2/PHASE3UNKNOWN
Quantitating the Impact of Plerixafor PHASE1/PHASE2UNKNOWN
Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients PHASE1/PHASE2COMPLETED
Exploratory Regimen of Basiliximab for Treatment of Pulmonary Cytokine Storm in SARS-CoV-2 Hospitalized Adult Patients PHASE2UNKNOWN
Trial of X4P-001 in Participants With Advanced Renal Cell Carcinoma PHASE1/PHASE2COMPLETED
Plerixafor and Granulocyte Colony-stimulating Factor (G-CSF) in Combination With Azacitidine for the Treatment of Myelodysplastic Syndrome (MDS) PHASE1COMPLETED
First Time in Human Study With GSK1325756 PHASE1COMPLETED
RP72 Monotherapy and in Combination With Gemcitabine in Patients With Pancreatic Cancer PHASE1UNKNOWN
Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC) PHASE1COMPLETED
68Ga-JH12 PET/CT: Dosimetry and Biodistribution Study EARLY_PHASE1RECRUITING
Value of Chemokine Receptor CXCR4 Imaging for Diagnosis and Prognostic Evaluation in Lymphoproliferative Diseases EARLY_PHASE1UNKNOWN
Chemokine Receptor CXCR4-targeting Molecular Imaging for Metabolic Characterization of Multiple Myeloma and Lymphoma EARLY_PHASE1UNKNOWN
Application of 68Ga-Pentixafor PET/CT for Thymoma EARLY_PHASE1UNKNOWN
Evaluation of CCR6 Gene Expression and Circulating CCL20 Levels as Potential Biomarkers in Rheumatoid Arthritis nanNOT_YET_RECRUITING
Measuring the Healthy Pediatric Inflammatory Response to Vaccination. nanENROLLING_BY_INVITATION
The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma nanUNKNOWN
ELR+CXCL Cytokines in Metastatic Kidney Cancers: Predictive Markers of Resistance to Sunitinib nanCOMPLETED
The Influence of Extracorporeal Photopheresis on Skin Sclerosis nanCOMPLETED
The Role of MMPs in the CXCL12-Induced Invasion of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma nanUNKNOWN
Involvement of Skeletal Muscle Fibrocytes in sarcOpenia in Patients With Chronic ObstRuctive Pulmonary Disease nanCOMPLETED
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia nanUNKNOWN
Evaluating Urinary CXCL10 for Enhanced Detection of Acute Rejection in Kidney Transplant Patients With Low DD-CFDNA nanRECRUITING
Comparative Study Between Alzheimer's and Multi-infarct Dementia nanUNKNOWN
Chemokine (CXCL13) as Anew Marker in Diagnosis of SLE nanUNKNOWN
LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia nanRECRUITING
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism. nanNOT_YET_RECRUITING
Inflammatory Biomarkers in Seizure nanUNKNOWN
Inflammatory Biomarkers in Psychogenic Non-epileptic Seizure nanUNKNOWN
The Role of Stromal Cell-Derived Factor-1 (SDF-1)/CXC Chemokine Receptor 4 (CXCR4) in Metastasis of Laryngeal and Hypopharyngeal Squamous Cell Carcinoma nanUNKNOWN
Circular RNA and Chemerin in Breast Cancer Patient nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a CXCR6 binder may also engage these)

ProteinNameSimilarity
Q9N0Z0 — 1.000 Q9N0Z0 →
Q9XT45 — 1.000 Q9XT45 →
O18983 — 1.000 O18983 →
O19024 — 1.000 O19024 →
Q9TV16 — 1.000 Q9TV16 →
Q9BDS6 — 0.999 Q9BDS6 →
Q9TSQ8 — 0.999 Q9TSQ8 →
Q95ND1 — 0.997 Q95ND1 →
Q95NC9 — 0.996 Q95NC9 →
Q95NC1 — 0.996 Q95NC1 →
O62743 — 0.996 O62743 →
O54814 — 0.996 O54814 →
O97882 — 0.996 O97882 →
P61815 — 0.995 P61815 →
Q95ND2 — 0.995 Q95ND2 →
Q9TV48 — 0.995 Q9TV48 →
Q95ND0 — 0.995 Q95ND0 →
Q2KTE1 — 0.995 Q2KTE1 →
Q8HZT9 — 0.995 Q8HZT9 →
P56493 — 0.995 P56493 →
P56439 — 0.994 P56439 →
Q2Y2P0 — 0.994 Q2Y2P0 →
Q95NE8 — 0.994 Q95NE8 →
Q3LSL6 — 0.994 Q3LSL6 →
Q6WN98 — 0.994 Q6WN98 →
P61755 — 0.994 P61755 →
P32303 — 0.994 P32303 →
Q764M9 — 0.994 Q764M9 →
Q9TV47 — 0.994 Q9TV47 →
Q95NC2 — 0.994 Q95NC2 →