Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.44 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21516509 | 0.82 | CDK2 (0.45) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL12384824 | 0.81 | CCNE1 (0.41) | MEN1KMT2AALDH1A1CCNE2CCNE1 | |
| SCHEMBL9072844 | 0.81 | CCNE1 (0.62) | RAB9AMEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL9071847 | 0.80 | CCNE2 (0.47) | RAB9AALDH1A1NPC1POLBCCNE2 | |
| SCHEMBL999233 | 0.80 | CCNE1 (0.43) | RAB9AALDH1A1NPC1CCNE2CCNE1 | |
| SCHEMBL999125 | 0.80 | CCNE1 (0.43) | RAB9AALDH1A1NPC1CCNE2CCNE1 | |
| SCHEMBL998518 | 0.80 | CCNE1 (0.43) | RAB9AALDH1A1NPC1CCNE2CCNE1 | |
| SCHEMBL1000176 | 0.80 | CCNE1 (0.43) | RAB9AALDH1A1NPC1CCNE2CCNE1 | |
| SCHEMBL999286 | 0.80 | CCNE1 (0.43) | RAB9AALDH1A1NPC1CCNE2CCNE1 | |
| SCHEMBL2667657 | 0.79 | CDK2 (0.46) | RAB9AMEN1KMT2ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066145-A1 | HETEROARYL-UREAS AND THEIR USE AS GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-07-21 | — | — | WO | disclosed |