Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 13/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | APOB | P04114 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666495 | 0.92 | GCGR (0.44) | GCGRPPARDMAPTFFAR1 | |
| SCHEMBL2666451 | 0.92 | GCGR (0.48) | GCGRPPARDPPARAPPARGMCL1 | |
| SCHEMBL2654978 | 0.91 | MAPT (0.39) | GCGRPPARDPPARAPPARGMAPT | |
| SCHEMBL2653931 | 0.90 | HPGD (0.39) | GCGRPPARDPPARAPPARGMAPT | |
| SCHEMBL2653083 | 0.90 | HPGD (0.41) | GCGRPPARDPPARAPPARGMAPT | |
| SCHEMBL9072397 | 0.89 | PPARD (0.41) | GCGRPPARDPPARAPPARGSPHK2 | |
| SCHEMBL2652772 | 0.89 | HPGD (0.42) | GCGRPPARDPPARAPPARGMAPT | |
| SCHEMBL2653672 | 0.88 | GCGR (0.39) | GCGRPPARDPPARAPPARGMAPT | |
| SCHEMBL2653427 | 0.87 | GCGR (0.40) | GCGRPPARDPPARAPPARGMAPT | |
| SCHEMBL2654616 | 0.87 | GCGR (0.40) | GCGRPPARDPPARAPPARGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |