Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666428 | 0.92 | GCGR (0.40) | GCGRFFAR1PPARDMAPT | |
| SCHEMBL2653964 | 0.92 | GCGR (0.53) | GCGRMEN1KMT2AACKR3L3MBTL1 | |
| SCHEMBL2654238 | 0.91 | GCGR (0.43) | GCGRMEN1KMT2AACKR3L3MBTL1 | |
| SCHEMBL2653812 | 0.90 | GCGR (0.42) | GCGRMEN1KMT2AACKR3VDR | |
| SCHEMBL2652386 | 0.89 | GCGR (0.42) | GCGRMEN1KMT2AACKR3L3MBTL1 | |
| SCHEMBL2654307 | 0.89 | HPGD (0.43) | GCGRMEN1KMT2AACKR3L3MBTL1 | |
| SCHEMBL2653233 | 0.88 | GCGR (0.43) | GCGRMEN1KMT2AACKR3L3MBTL1 | |
| SCHEMBL2654872 | 0.85 | GCGR (0.42) | GCGRMEN1KMT2AACKR3L3MBTL1 | |
| SCHEMBL13647290 | 0.83 | GCGR (0.44) | GCGRMEN1KMT2AACKR3L3MBTL1 | |
| SCHEMBL2666451 | 0.83 | GCGR (0.48) | GCGRFFAR1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |