Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24936161 | 0.88 | KCNH2 (0.66) | KCNH2CHEK1DYRK1A | |
| SCHEMBL30522667 | 0.88 | KCNH2 (0.66) | KCNH2CHEK1DYRK1A | |
| SCHEMBL18955140 | 0.85 | HSD17B10 (0.48) | KCNH2CHEK1HSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL26668647 | 0.85 | CHEK1 (0.48) | KCNH2CHEK1HSD17B10DYRK1AALDH1A1 | |
| SCHEMBL29045170 | 0.83 | CHEK1 (0.47) | KCNH2CHEK1HSD17B10DYRK1AGAA | |
| SCHEMBL24936150 | 0.80 | KCNH2 (0.57) | KCNH2CHEK1DYRK1A | |
| SCHEMBL25237329 | 0.76 | MCHR1 (0.43) | ALDH1A1L3MBTL1MCHR1GAA | |
| SCHEMBL24945078 | 0.74 | KCNH2 (0.51) | KCNH2CHEK1 | |
| SCHEMBL30522689 | 0.74 | KCNH2 (0.51) | KCNH2CHEK1 | |
| SCHEMBL19007838 | 0.73 | KCNH2 (0.51) | KCNH2CHEK1HSD17B10MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023229032-A1 | THERAPEUTIC FOR CANCER REFRACTORY TO IMMUNE CHECKPOINT INHIBITOR | 住友ファーマ株式会社 | 2023-11-30 | — | — | WO | disclosed |