Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 6/20 | 0.43 |
| ▸ | IGF1R | P08069 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19823081 | 0.99 | RET (0.45) | RETAURKAAURKBJAK3IGF1R | |
| SCHEMBL19364237 | 0.96 | JAK3 (0.46) | RETAURKAAURKBJAK3IGF1R | |
| SCHEMBL29970687 | 0.82 | AURKA (0.52) | RETAURKAAURKBJAK3IGF1R | |
| SCHEMBL12303128 | 0.80 | GSK3A (0.55) | RETIGF1R | |
| SCHEMBL28462357 | 0.76 | IGF1R (0.53) | RETAURKAAURKBJAK3IGF1R | |
| SCHEMBL19364254 | 0.75 | NOS3 (0.50) | RETAURKAAURKBJAK3IGF1R | |
| SCHEMBL13268332 | 0.74 | AURKA (0.54) | RETAURKAAURKBJAK3FGFR1 | |
| SCHEMBL802067 | 0.73 | AURKA (0.38) | AURKAAURKBIGF1RFGFR1KDR | |
| SCHEMBL19626476 | 0.72 | KMT2A (0.54) | JAK3JAK1TYK2LRRK2 | |
| SCHEMBL28921761 | 0.72 | ITK (0.43) | RETAURKAAURKBJAK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371171-B1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORP (US) | 2023-10-25 | — | — | EP | disclosed |