SCHEMBL26670523

SCHEMBL26670523

COC(=O)C1(N)CC1(F)F

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.34
LMNA P02545 1/20 0.34
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL26670486 0.98 NPSR1 (0.33) NPSR1LMNAMEN1KMT2A
SCHEMBL13639011 0.78 MEN1 (0.37) NPSR1LMNAMEN1KMT2A
SCHEMBL1063469 0.76
SCHEMBL11941461 0.76
SCHEMBL22647547 0.74 NPSR1 (0.33) NPSR1LMNAMEN1KMT2A
SCHEMBL1434492 0.74 NPSR1 (0.38) NPSR1LMNAMEN1KMT2A
SCHEMBL11941446 0.73 MGAM (0.38) LMNA
Hydrochloric Acid SCHEMBL22395980 0.73 LMNA (0.32) NPSR1LMNAMEN1KMT2A
Hydrochloric Acid SCHEMBL1434491 0.73 NPSR1 (0.36) NPSR1LMNAMEN1KMT2A
SCHEMBL17546712 0.71 NPSR1 (0.34) NPSR1LMNAMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023230542-A2 PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO disclosed
WO-2023230542-A2 PYRAZOLO[1,5-a]PYRIDINE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO disclosed