Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776232 | 0.85 | GCK (0.61) | GCKKCNH2 | |
| SCHEMBL1775917 | 0.84 | GCK (0.64) | GCKKCNH2 | |
| SCHEMBL2667121 | 0.83 | GCK (0.46) | GCKKCNH2HPGDSNPC1RAB9A | |
| SCHEMBL1775477 | 0.77 | GCK (0.58) | GCKKCNH2 | |
| SCHEMBL2654946 | 0.73 | NPC1 (0.52) | GCKKCNH2HPGDSNPC1RAB9A | |
| SCHEMBL2667078 | 0.72 | NPC1 (0.66) | GCKKCNH2HPGDSNPC1RAB9A | |
| SCHEMBL2659386 | 0.72 | GCK (0.78) | GCKKCNH2 | |
| SCHEMBL1775877 | 0.72 | GCK (0.61) | GCKKCNH2 | |
| SCHEMBL1775775 | 0.72 | GCK (0.62) | GCKKCNH2 | |
| SCHEMBL1427233 | 0.71 | GCK (0.63) | GCKKCNH2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006125972-A1 | HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |