Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 14/20 | 0.57 |
| ▸ | GCG | P01275 | 9/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | GLP1R | P43220 | 2/20 | 0.53 |
| ▸ | GIPR | P48546 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765173 | 0.88 | GCGR (0.54) | GCGRGCGGLP1RGIPRCHRM5 | |
| SCHEMBL1765694 | 0.88 | GCGR (0.56) | GCGRGCGGLP1RCHRM5 | |
| SCHEMBL12648837 | 0.87 | SLC6A3 (0.47) | GCGRGCGSLC6A3GLP1RGIPR | |
| SCHEMBL1765404 | 0.87 | SLC6A3 (0.47) | GCGRGCGSLC6A3GLP1RGIPR | |
| SCHEMBL1765323 | 0.86 | GCGR (0.60) | GCGRGCGGLP1RGIPRCHRM5 | |
| SCHEMBL1765142 | 0.85 | GCGR (0.61) | GCGRGCGGLP1RGIPRCHRM5 | |
| SCHEMBL2348051 | 0.85 | GCGR (0.64) | GCGRGCGGLP1RGIPRCHRM5 | |
| SCHEMBL2348059 | 0.85 | GCGR (0.64) | GCGRGCGGLP1RGIPRCHRM5 | |
| SCHEMBL2271785 | 0.85 | GCGR (0.64) | GCGRGCGGLP1RGIPRCHRM5 | |
| SCHEMBL1765750 | 0.85 | GCGR (0.64) | GCGRGCGGLP1RGIPRCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2159221-A1 | Glucagon receptor antagonists, preparation and therapeutic uses | Eli Lilly & Company (US) | 2010-03-03 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |