Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.76 |
| ▸ | PLK3 | Q9H4B4 | 9/20 | 0.76 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23657651 | 0.94 | TRPV1 (0.68) | PLK1PLK3TRPV1 | |
| SCHEMBL8079556 | 0.85 | PLK1 (0.71) | PLK1PLK3TRPV1 | |
| SCHEMBL11576911 | 0.85 | PLK1 (0.81) | PLK1PLK3TRPV1 | |
| SCHEMBL11574896 | 0.85 | PLK1 (0.81) | PLK1PLK3TRPV1 | |
| SCHEMBL26671722 | 0.83 | PLK1 (0.68) | PLK1PLK3TRPV1 | |
| SCHEMBL9374962 | 0.83 | HDAC1 (0.62) | PLK1PLK3 | |
| SCHEMBL11699043 | 0.83 | NPC1 (0.64) | PLK1PLK3TRPV1 | |
| SCHEMBL28808948 | 0.83 | PLK1 (0.97) | PLK1PLK3 | |
| SCHEMBL19491384 | 0.82 | PLK1 (0.70) | PLK1PLK3TRPV1 | |
| SCHEMBL9713903 | 0.82 | PLK1 (0.74) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230338316-A1 | ABBAPOLINS AS INHIBITORS AND DEGRADERS OF POLO-LIKE KINASES | UNIVERSITY OF SOUTH CAROLINA | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230338316-A1 | ABBAPOLINS AS INHIBITORS AND DEGRADERS OF POLO-LIKE KINASES | PLK1, PLK2, POLK | PLK1 1/4885PLK3 69/4885TRPV1 4755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.