Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.97 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.97 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.65 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.65 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.65 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.65 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.65 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1464667 | 0.96 | PLK1 (0.90) | PLK1PLK3 | |
| SCHEMBL26672187 | 0.83 | PLK1 (0.76) | PLK1PLK3 | |
| SCHEMBL14075268 | 0.83 | PLK1 (0.75) | PLK1PLK3 | |
| SCHEMBL8079556 | 0.82 | PLK1 (0.71) | PLK1PLK3 | |
| SCHEMBL2028671 | 0.81 | DHODH (0.86) | PLK1PLK3 | |
| SCHEMBL19491384 | 0.81 | PLK1 (0.70) | PLK1PLK3 | |
| SCHEMBL1464569 | 0.81 | PLK1 (0.66) | PLK1PLK3 | |
| SCHEMBL16495561 | 0.81 | PLK1 (0.72) | PLK1PLK3 | |
| SCHEMBL5696419 | 0.80 | DHODH (0.69) | PLK1PLK3 | |
| SCHEMBL15535467 | 0.80 | PLK1 (0.68) | PLK1PLK3TRPA1TRPM2PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114831977-A | Application of benzoic acid derivatives as TRPM2 protein inhibitors | 北京大学 | 2022-08-02 | — | — | CN | claimed |
| CN-114831977-B | Application of benzoic acid derivative as TRPM2 protein inhibitor | 北京大学 | 2023-12-19 | — | — | CN | disclosed |
| CN-114831977-A | Application of benzoic acid derivatives as TRPM2 protein inhibitors | 北京大学 | 2022-08-02 | — | — | CN | disclosed |