Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.38 |
| ▸ | GIPR | P48546 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252405 | 0.84 | GCGR (0.46) | GCGRGIPRHDAC1CYP2C9 | |
| SCHEMBL2253932 | 0.73 | GCGR (0.48) | GCGRGIPRHDAC1CYP2C9 | |
| SCHEMBL2667899 | 0.73 | GCGR (0.44) | GCGRGIPRHDAC1ACKR3 | |
| SCHEMBL13003065 | 0.71 | GCGR (0.33) | GCGRGIPRHDAC1ACKR3 | |
| SCHEMBL2667900 | 0.71 | GCGR (0.59) | GCGRGIPRCYP2C9 | |
| SCHEMBL13003191 | 0.70 | GCGR (0.56) | GCGRGIPRCYP2C9 | |
| SCHEMBL2667427 | 0.69 | GCGR (0.52) | GCGRGIPRHDAC1 | |
| SCHEMBL2253874 | 0.68 | GCGR (0.42) | GCGRGIPRCYP2C9 | |
| SCHEMBL2251454 | 0.66 | GCGR (0.76) | GCGRGIPRHDAC1 | |
| SCHEMBL2250281 | 0.66 | GCGR (0.43) | GCGRGIPRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004069158-A2 | SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2004-08-19 | — | — | WO | disclosed |