Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.78 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9070860 | 0.91 | GCK (0.68) | GCKRAB9AMEN1NPC1ALDH1A1 | |
| SCHEMBL3602195 | 0.88 | GCK (1.00) | GCKRAB9AMEN1NPC1ALDH1A1 | |
| SCHEMBL2667726 | 0.87 | GCK (0.64) | GCKRAB9ANPC1 | |
| SCHEMBL2667443 | 0.87 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL2667366 | 0.87 | TDP1 (0.66) | GCKMEN1ALDH1A1GAAKMT2A | |
| SCHEMBL2667386 | 0.87 | TDP1 (0.64) | GCKMEN1ALDH1A1GAAKMT2A | |
| SCHEMBL2667772 | 0.86 | GCK (0.60) | GCKRAB9ANPC1 | |
| SCHEMBL9070935 | 0.86 | GCK (0.58) | GCKRAB9ANPC1ALDH1A1 | |
| SCHEMBL2667525 | 0.85 | GCK (0.58) | GCKMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL2667676 | 0.85 | GCK (0.58) | GCKMEN1ALDH1A1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |