Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 11/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667543 | 0.84 | GCK (0.51) | GCKKCNH2RAB9ANPC1 | |
| SCHEMBL9070993 | 0.83 | GCK (0.68) | GCKKCNH2RAB9ANPC1HPGDS | |
| SCHEMBL2667388 | 0.81 | GCK (0.57) | GCKKCNH2RAB9AMEN1KMT2A | |
| SCHEMBL9070949 | 0.81 | GCK (0.66) | GCKKCNH2KMT2A | |
| SCHEMBL2667725 | 0.81 | GCK (0.66) | GCK | |
| SCHEMBL2667519 | 0.81 | PTGDR (0.56) | GCKKCNH2 | |
| SCHEMBL2656936 | 0.80 | NPC1 (0.50) | GCKKCNH2RAB9ANPC1HPGDS | |
| SCHEMBL943092 | 0.80 | NPC1 (0.50) | GCKKCNH2RAB9ANPC1HPGDS | |
| SCHEMBL2667728 | 0.79 | GCK (0.63) | GCKKCNH2MEN1KMT2A | |
| SCHEMBL2667589 | 0.78 | GCK (0.67) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083553-A1 | AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS | RHEOSCIENCE A/S (DK) | 2009-07-09 | — | — | WO | disclosed |