SCHEMBL2667973

SCHEMBL2667973

COC[C@@H](C)Oc1cc(C(=O)Nc2ccn(C)n2)cc(Oc2ccc(C(=O)N3CCCC3)cc2)n1

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.77
KCNH2 Q12809 8/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2667788 0.94 GCK (0.71) GCKKCNH2
SCHEMBL2667780 0.93 GCK (0.69) GCKKCNH2
SCHEMBL2667355 0.90 GCK (0.65) GCKKCNH2
SCHEMBL1146753 0.89 GCK (0.97) GCKKCNH2
SCHEMBL13891610 0.89 GCK (0.97) GCKKCNH2
SCHEMBL13891640 0.87 GCK (1.00) GCKKCNH2
SCHEMBL1146765 0.87 GCK (1.00) GCKKCNH2
SCHEMBL2667589 0.87 GCK (0.67) GCKKCNH2
SCHEMBL9070941 0.85 GCK (0.60) GCKKCNH2
SCHEMBL9071056 0.85 GCK (0.59) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009083553-A1 AZINE COMPOUNDS AS GLUCOKINASE ACTIVATORS RHEOSCIENCE A/S (DK) 2009-07-09 WO disclosed