Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 15/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087567 | 1.00 | GCK (0.43) | GCKSCDKCNH2CYP1A2CYP3A4 | |
| SCHEMBL2086592 | 0.94 | GCK (0.42) | GCKKCNH2 | |
| SCHEMBL2085254 | 0.83 | GCK (0.49) | GCK | |
| SCHEMBL708896 | 0.83 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL708895 | 0.83 | GCK (0.52) | GCKKCNH2 | |
| SCHEMBL2087976 | 0.81 | GCK (0.41) | GCKKCNH2 | |
| SCHEMBL2085163 | 0.81 | GCK (0.44) | GCKKCNH2 | |
| SCHEMBL2088032 | 0.81 | GCK (0.46) | GCKKCNH2 | |
| SCHEMBL2668030 | 0.79 | GCK (0.41) | GCKKCNH2 | |
| SCHEMBL2086073 | 0.78 | GCK (0.41) | GCKSCDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006125958-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4 , 5B] PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |