SCHEMBL26680907

SCHEMBL26680907

CS(=O)(=O)NC(=O)c1ccc(N2CCN(Cc3ccccc3-c3cncc(O)c3)CC2)cc1

nearest known ligand 0.70

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 19/20 0.70
BAK1 Q16611 5/20 0.70
BCL2L1 Q07817 15/20 0.53
CHEK1 O14757 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26680260 0.91 BCL2 (0.57) BCL2BAK1BCL2L1
SCHEMBL26683021 0.91 BCL2 (0.57) BCL2BAK1BCL2L1CHEK1
SCHEMBL26681641 0.90 BCL2 (0.56) BCL2BAK1BCL2L1
SCHEMBL29792980 0.90 BCL2 (0.56) BCL2BAK1BCL2L1
SCHEMBL26682987 0.88 BCL2 (0.73) BCL2BAK1BCL2L1
SCHEMBL29793220 0.88 BCL2 (0.58) BCL2BAK1BCL2L1
SCHEMBL26680650 0.88 BCL2 (0.58) BCL2BAK1BCL2L1
SCHEMBL26681005 0.87 BCL2 (0.65) BCL2BAK1BCL2L1CHEK1
SCHEMBL26683152 0.86 BCL2 (0.52) BCL2BAK1BCL2L1CHEK1
SCHEMBL26681292 0.86 BCL2 (0.52) BCL2BAK1BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4279476-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-22 EP disclosed