Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 13/20 | 0.65 |
| ▸ | PDE5A | O76074 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711966 | 0.86 | PRMT5 (0.67) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL711172 | 0.84 | PRMT5 (0.60) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL15972282 | 0.80 | PRMT5 (1.00) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL2668280 | 0.78 | PRMT5 (0.54) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL711302 | 0.76 | PRMT5 (0.57) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL711173 | 0.73 | AURKA (0.56) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL14090341 | 0.73 | PRMT5 (0.70) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL709335 | 0.73 | PRMT5 (0.61) | PRMT5PDE5APDE4APDE4BPDE4C | |
| SCHEMBL11155883 | 0.71 | AURKA (0.67) | PRMT5PDE5AAURKA | |
| SCHEMBL711692 | 0.71 | PRMT5 (0.56) | PRMT5PDE5APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007028135-A2 | IMIDAZOPYRIDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-08 | — | — | WO | disclosed |