Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL711302 | 0.89 | PRMT5 (0.57) | PRMT5AURKAFGFR1FGFR2FGFR3 | |
| SCHEMBL711172 | 0.78 | PRMT5 (0.60) | PRMT5AURKAFGFR1FGFR2FGFR3 | |
| SCHEMBL2668291 | 0.78 | PRMT5 (0.65) | PRMT5AURKADHODHPDE5APDE4A | |
| SCHEMBL711966 | 0.72 | PRMT5 (0.67) | PRMT5AURKADHODHPDE5APDE4A | |
| SCHEMBL711173 | 0.72 | AURKA (0.56) | PRMT5AURKAPDE5APDE4APDE4B | |
| SCHEMBL2668141 | 0.72 | DHODH (0.41) | PRMT5DHODHGRM2MAOADYRK1A | |
| SCHEMBL711692 | 0.71 | PRMT5 (0.56) | PRMT5AURKAFGFR1FGFR2FGFR3 | |
| SCHEMBL15972282 | 0.71 | PRMT5 (1.00) | PRMT5AURKADHODHPDE5APDE4A | |
| SCHEMBL13639545 | 0.71 | GRM5 (0.52) | PRMT5FGFR1DHODHGRM2MAOA | |
| SCHEMBL10206642 | 0.70 | MAPK1 (0.47) | PRMT5DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007028135-A2 | IMIDAZOPYRIDINE COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-08 | — | — | WO | disclosed |