Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.36 |
| ▸ | HTR3B | O95264 | 4/20 | 0.36 |
| ▸ | HTR3A | P46098 | 4/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26683185 | 0.73 | PBRM1 (0.56) | HTR2CCYP1A2CYP2C19KDM4ESCN4A | |
| SCHEMBL3688205 | 0.70 | HTR2C (0.46) | HTR2CALDH1A1HTR1AHTR2AKDM4E | |
| SCHEMBL195335 | 0.68 | BPTF (0.49) | BPTFADRB1CHRM2CHRM4CHRM1 | |
| SCHEMBL195203 | 0.67 | BPTF (0.51) | BPTFADRB1CHRM2CHRM4CHRM1 | |
| SCHEMBL30282824 | 0.67 | BPTF (0.51) | BPTFADRB1CHRM2CHRM4CHRM1 | |
| SCHEMBL26683356 | 0.67 | TDP1 (0.33) | — | |
| Hydrochloric Acid SCHEMBL23037230 | 0.67 | BPTF (0.47) | BPTFADRB1CHRM2CHRM4CHRM1 | |
| SCHEMBL8339118 | 0.66 | BPTF (0.50) | BPTFADRB1CHRM2CHRM4CHRM1 | |
| SCHEMBL30658007 | 0.66 | BPTF (0.43) | BPTFADRB1CHRM2CHRM4CHRM1 | |
| SCHEMBL26653837 | 0.66 | BPTF (0.43) | BPTFADRB1CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250304596-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-10-02 | — | — | US | disclosed |
| EP-4522277-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220137-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220137-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250304596-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | VHL, BRCA1, SF3B5 | BPTF 175/4885ADRB1 3248/4885CHRM2 4685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.