SCHEMBL2668337

SCHEMBL2668337

Cn1ccnc1COc1ccc(OCC2=CC=CCC2)cc1-c1nc2cccnc2[nH]1

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
KDM4E B2RXH2 1/20 0.32
SYK P43405 1/20 0.31
HTT P42858 1/20 0.31
CASP3 P42574 1/20 0.31
SENP8 Q96LD8 1/20 0.31
SENP6 Q9GZR1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2668258 0.90 PDGFRB (0.31) MEN1KMT2A
SCHEMBL2668254 0.88 MEN1 (0.32) MEN1KMT2A
SCHEMBL711188 0.83 CYP3A4 (0.41) MEN1KMT2AKDM4E
SCHEMBL2668272 0.81 SYK (0.34) SYK
SCHEMBL712707 0.73 PRMT5 (0.40)
SCHEMBL712174 0.72 MAPT (0.36) MEN1KMT2A
SCHEMBL10206607 0.71 CYP3A4 (0.51) HTT
SCHEMBL711039 0.69 PRMT5 (0.41) MEN1KMT2A
SCHEMBL10206627 0.68 CYP3A4 (0.46) SYK
SCHEMBL10206608 0.68 SYK (0.46) MEN1KMT2ASYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007028135-A2 IMIDAZOPYRIDINE COMPOUNDS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-03-08 WO disclosed