Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31543243 | 1.00 | JAK2 (0.37) | JAK2PDPK1DYRK1AIDO1TDO2 | |
| SCHEMBL21055463 | 0.80 | GABRP (0.36) | JAK2PDPK1DYRK1AIDO1TDO2 | |
| SCHEMBL30056844 | 0.80 | GABRP (0.36) | JAK2PDPK1DYRK1AIDO1TDO2 | |
| SCHEMBL16340015 | 0.80 | PDPK1 (0.35) | JAK2PDPK1DYRK1AIDO1TDO2 | |
| SCHEMBL30661625 | 0.80 | PDPK1 (0.35) | JAK2PDPK1DYRK1AIDO1TDO2 | |
| SCHEMBL24159871 | 0.76 | TTK (0.33) | JAK2PDPK1DYRK1ACHEK1 | |
| SCHEMBL29563762 | 0.76 | TTK (0.33) | JAK2PDPK1DYRK1ACHEK1 | |
| SCHEMBL24087052 | 0.76 | CHEK1 (0.45) | JAK2PDPK1CHEK1 | |
| SCHEMBL22580854 | 0.73 | MAPT (0.33) | JAK2DYRK1AMAP4K4CLK2MAP4K2 | |
| SCHEMBL31543364 | 0.70 | PIM1 (0.43) | JAK2PDPK1DYRK1AABL1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522612-A1 | TYK2 INHIBITORS | Biogen MA Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220046-A1 | TYK2 INHIBITORS | BIOGEN MA INC. (US) | 2023-11-16 | — | — | WO | disclosed |