Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30616800 | 1.00 | TRPA1 (0.42) | TRPA1LMNACYP2C9MEN1POLB | |
| SCHEMBL27540000 | 0.88 | TRPA1 (0.43) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL7377318 | 0.86 | TRPA1 (0.49) | TRPA1LMNACYP2C9MEN1POLB | |
| SCHEMBL27534345 | 0.81 | TRPA1 (0.35) | TRPA1 | |
| SCHEMBL28650154 | 0.77 | TRPA1 (0.40) | TRPA1LMNACA12CA9HSD17B10 | |
| SCHEMBL10499941 | 0.73 | TRPA1 (0.40) | TRPA1CA12CA9 | |
| SCHEMBL25341094 | 0.71 | TRPA1 (0.39) | TRPA1LMNACYP2C9MEN1KMT2A | |
| SCHEMBL9935517 | 0.71 | TRPA1 (0.47) | TRPA1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL9933270 | 0.70 | TRPA1 (0.43) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 | |
| SCHEMBL9934214 | 0.70 | TRPA1 (0.43) | TRPA1LMNAMAPK1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3935060-B1 | FUSED TRICYCLIC COMPOUNDS USEFUL AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2023-11-15 | — | — | EP | disclosed |