Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2221552 | 0.91 | MEN1 (0.67) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| Ammonia Solution, Strong SCHEMBL8149832 | 0.90 | MEN1 (0.65) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL11520379 | 0.88 | MEN1 (0.77) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL20414393 | 0.85 | MEN1 (0.88) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL26690453 | 0.81 | MEN1 (0.48) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL13970811 | 0.80 | KDM4E (0.55) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL13970839 | 0.78 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL3935647 | 0.77 | HTT (0.57) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL13900453 | 0.77 | HTT (0.58) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL19055370 | 0.77 | HTT (0.58) | MEN1KMT2ASMN1; SMN2HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |