Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26691214 | 0.81 | MEN1 (0.70) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL13970839 | 0.79 | MEN1 (0.49) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL28422762 | 0.77 | SLC6A2 (0.39) | ACHEKDM4EALDH1A1TDP1CHRM2 | |
| SCHEMBL14613959 | 0.76 | ACHE (0.44) | MEN1KMT2ASMN1; SMN2SCN8AHTT | |
| SCHEMBL31737438 | 0.74 | ACHE (0.43) | MEN1KMT2ASMN1; SMN2SCN8AHTT | |
| SCHEMBL170728 | 0.74 | ACHE (0.46) | MEN1KMT2ASMN1; SMN2ACHEKDM4E | |
| SCHEMBL19657536 | 0.74 | SLC6A4 (0.42) | MEN1KMT2ASMN1; SMN2SCN8AHTT | |
| SCHEMBL170719 | 0.73 | ACHE (0.50) | MEN1KMT2ASMN1; SMN2SCN8AACHE | |
| SCHEMBL2221552 | 0.71 | MEN1 (0.67) | MEN1KMT2ASMN1; SMN2HTTKDM4E | |
| SCHEMBL19099380 | 0.71 | GRIN2B (0.43) | SMN1; SMN2SCN8AHTTACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |