Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20828069 | 1.00 | ACHE (0.46) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL764748 | 1.00 | ACHE (0.46) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL17481893 | 0.83 | ACHE (0.46) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL28277722 | 0.83 | ACHE (0.46) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL6114620 | 0.81 | ACHE (0.44) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL21600873 | 0.81 | ACHE (0.44) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL25628030 | 0.81 | ACHE (0.44) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL11631917 | 0.81 | ACHE (0.44) | ACHEMAPKAPK2ALDH1A1HPGDACP3 | |
| SCHEMBL19176016 | 0.80 | HDAC4 (0.44) | ALDH1A1HPGDCYP3A4CYP2D6MAPT | |
| SCHEMBL16191558 | 0.80 | ACHE (0.48) | ACHEALDH1A1ACP3AOC3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883824-B2 | 3-(4-aminophenyl)-2-furancarboxylic acid derivative and pharmaceutically acceptable salt thereof | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2014-11-11 | — | — | US | disclosed |
| WO-2010131669-A1 | 3-(4-AMINOPHENYL)-2-FURANCARBOXYLIC ACID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | 大日本住友製薬株式会社 (JP) | 2010-11-18 | — | — | WO | disclosed |
| EP-1745047-B1 | PYRAZOLO[4,3-E]-1,2,4-TRIAZOLO[1,5-C]PYRIMIDINE ADENOSINE-A2A- RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2010-03-24 | — | — | EP | disclosed |