SCHEMBL2669313

SCHEMBL2669313

Cc1csc(Nc2ncccc2OCc2cccc3nc[nH]c23)n1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 18/20 0.68
GRM5 P41594 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2339141 0.99 GCK (0.67) GCKGRM5
SCHEMBL2669231 0.85 GCK (0.82) GCKGRM5
Hydrochloric Acid SCHEMBL2336812 0.84 GCK (0.81) GCKGRM5
SCHEMBL2342162 0.81 GCK (1.00) GCKGRM5
Hydrochloric Acid SCHEMBL2339960 0.81 GCK (0.98) GCKGRM5
SCHEMBL2339749 0.80 GCK (0.76) GCKGRM5
SCHEMBL2342536 0.79 GCK (0.73) GCKGRM5
SCHEMBL2337781 0.77 GCK (0.71) GCKGRM5
SCHEMBL2334151 0.77 GCK (1.00) GCKGRM5
SCHEMBL13439330 0.76 GCK (1.00) GCKGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1948652-B1 GLUCOKINASE ACTIVATORS ARRAY BIOPHARMA INC (US) 2011-08-24 EP disclosed
WO-2007053345-A1 GLUCOKINASE ACTIVATORS ARRAY BIOPHARMA INC. (US) 2007-05-10 WO disclosed