Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.31 |
| ▸ | ELAVL3 | Q14576 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.30 |
| ▸ | BACE1 | P56817 | 3/20 | 0.30 |
| ▸ | MET | P08581 | 2/20 | 0.30 |
| ▸ | BCL2 | P10415 | 2/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.30 |
| ▸ | SNCA | P37840 | 2/20 | 0.30 |
| ▸ | PGD | P52209 | 2/20 | 0.30 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | RECQL | P46063 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | ECE1 | P42892 | 1/20 | 0.30 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.30 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669379 | 0.78 | GCK (0.35) | KCNH2 | |
| SCHEMBL2644275 | 0.73 | KDM4E (0.42) | HSP90AB1ELAVL3DYRK1ABACE1MET | |
| SCHEMBL2669277 | 0.69 | PLK1 (0.30) | — | |
| SCHEMBL643549 | 0.69 | NPC1 (0.45) | KCNH2 | |
| SCHEMBL2669399 | 0.64 | GCK (0.36) | KCNH2 | |
| SCHEMBL2666697 | 0.60 | TDP1 (0.33) | TDP1MMP2 | |
| SCHEMBL13209318 | 0.60 | GCK (0.34) | KCNH2 | |
| SCHEMBL15780559 | 0.59 | NPC1 (0.47) | KCNH2 | |
| SCHEMBL13209296 | 0.58 | GCK (0.42) | — | |
| SCHEMBL18463626 | 0.58 | CRBN (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007122482-A1 | FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF GLUCOKINASE-MEDIATED DISEASES | PFIZER PRODUCTS INC. (US) | 2007-11-01 | — | — | WO | disclosed |