Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718782 | 0.82 | GCK (0.72) | GCKLNPEPPTGESALOX5CACNA1B | |
| SCHEMBL9072543 | 0.81 | GCK (0.62) | GCKHPGDLNPEPPTGESALOX5 | |
| SCHEMBL12020984 | 0.81 | GCK (0.62) | GCKHPGDLNPEPPTGESALOX5 | |
| SCHEMBL14017936 | 0.81 | GCK (0.59) | GCKHPGDLNPEPPTGESALOX5 | |
| SCHEMBL2657438 | 0.80 | GCK (0.64) | GCKHPGDLNPEPPTGESALOX5 | |
| SCHEMBL1299707 | 0.77 | HPGD (0.62) | HPGDPPARGPPARALTA4H | |
| SCHEMBL18002195 | 0.74 | ALDH1A3 (0.46) | ALDH1A3HTR1A | |
| SCHEMBL1121444 | 0.73 | ALDH1A3 (0.63) | HPGDALDH1A3PPARGPPARAPPARD | |
| SCHEMBL2666392 | 0.73 | GCK (0.60) | GCKHPGDLNPEPCACNA1BPPARG | |
| SCHEMBL2664775 | 0.73 | GCK (0.68) | GCKHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023718-A2 | NOVEL ACTIVATORS OF GLUCOKINASE | METABASIS THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | WO | disclosed |