Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.64 |
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | AADAC | P22760 | 1/20 | 0.52 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4342071 | 0.87 | EPHX2 (0.68) | EPHX2IGF1RTDP1FAAHAADAC | |
| SCHEMBL26697317 | 0.86 | P2RX1 (0.55) | EPHX2NPC1RAB9AMAPTHTT | |
| SCHEMBL18031167 | 0.83 | EPHX2 (0.86) | EPHX2TDP1FAAHAADACSTING1 | |
| SCHEMBL22263059 | 0.83 | MEN1 (0.72) | EPHX2IGF1RTDP1FAAHSTING1 | |
| SCHEMBL26697260 | 0.83 | CA12 (0.64) | EPHX2RAB9AMEN1MAPTKMT2A | |
| SCHEMBL4346219 | 0.81 | EPHX2 (0.71) | EPHX2IGF1RTDP1FAAHSTING1 | |
| SCHEMBL4354666 | 0.81 | EPHX2 (0.62) | EPHX2IGF1RTDP1FAAHSTING1 | |
| SCHEMBL29757932 | 0.81 | RAB9A (0.56) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL21750906 | 0.81 | RAB9A (0.56) | NPC1RAB9AMEN1KMT2AHTT | |
| SCHEMBL4343951 | 0.80 | EPHX2 (0.69) | EPHX2IGF1RTDP1FAAHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |