Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.73 |
| ▸ | FLT1 | P17948 | 8/20 | 0.73 |
| ▸ | FLT4 | P35916 | 8/20 | 0.73 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.66 |
| ▸ | KIT | P10721 | 2/20 | 0.66 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | MET | P08581 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | BCR | P11274 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.66 |
| ▸ | HTR2A | P28223 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653965 | 0.92 | KDR (0.78) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL19645596 | 0.90 | KDR (0.84) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL15962801 | 0.89 | KDR (0.82) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL24520230 | 0.89 | KDR (0.82) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL24520229 | 0.89 | KDR (0.74) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL15962835 | 0.89 | KDR (0.79) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL26697235 | 0.88 | KDR (0.73) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL26697264 | 0.88 | KDR (0.71) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL26697250 | 0.87 | KDR (0.72) | KDRFLT1FLT4PDGFRAKIT | |
| SCHEMBL26697299 | 0.87 | KDR (0.70) | KDRFLT1FLT4PDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920703-B | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| WO-2023226323-A1 | QUINAZOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 天津济坤医药科技有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-114920703-A | Quinazoline derivative and preparation method and application thereof | 天津济坤医药科技有限公司 | 2022-08-19 | — | — | CN | disclosed |