Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 8/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | SIK1 | P57059 | 2/20 | 0.39 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.39 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616138 | 0.85 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2ACACBFGFR1 | |
| SCHEMBL2669747 | 0.83 | THRB (0.47) | NPC1RAB9ASMN1; SMN2ACACBFGFR1 | |
| SCHEMBL13002375 | 0.81 | HPGD (0.54) | NPC1RAB9ASMN1; SMN2FGFR1HPGD | |
| SCHEMBL2669850 | 0.80 | LCK (0.41) | NPC1RAB9AACACBFGFR1HPGD | |
| SCHEMBL1617120 | 0.80 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ACACBFGFR1 | |
| SCHEMBL1616776 | 0.80 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ACACBFGFR1 | |
| SCHEMBL1616093 | 0.80 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2ACACBFGFR1 | |
| SCHEMBL12222392 | 0.78 | FGFR1 (0.66) | NPC1RAB9ASMN1; SMN2FGFR1HPGD | |
| SCHEMBL1616031 | 0.76 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2FGFR1HPGD | |
| SCHEMBL1617011 | 0.76 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2FGFR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010055127-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2010-05-20 | — | — | WO | disclosed |