Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 14/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.59 |
| ▸ | AKT1 | P31749 | 3/20 | 0.53 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.48 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26698220 | 1.00 | ROCK1 (0.59) | ROCK1ROCK2AKT1MYLK4TACR3 | |
| SCHEMBL30771367 | 1.00 | ROCK1 (0.59) | ROCK1ROCK2AKT1MYLK4TACR3 | |
| SCHEMBL30771354 | 1.00 | ROCK1 (0.59) | ROCK1ROCK2AKT1MYLK4TACR3 | |
| SCHEMBL30771333 | 1.00 | ROCK1 (0.59) | ROCK1ROCK2AKT1MYLK4TACR3 | |
| SCHEMBL30771316 | 0.92 | ROCK2 (0.50) | ROCK1ROCK2AKT1MAPK1 | |
| SCHEMBL30771395 | 0.91 | AKT1 (0.49) | ROCK1ROCK2AKT1MYLK4TACR3 | |
| SCHEMBL30771302 | 0.91 | ROCK1 (0.49) | ROCK1ROCK2AKT1MYLK4TACR3 | |
| SCHEMBL30771350 | 0.90 | ROCK1 (0.53) | ROCK1ROCK2AKT1 | |
| SCHEMBL30771379 | 0.89 | ROCK1 (0.58) | ROCK1ROCK2AKT1MYLK4TACR3 | |
| SCHEMBL30771274 | 0.89 | ROCK1 (0.54) | ROCK1ROCK2AKT1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023226965-A1 | ROCK INHIBITORS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-11-30 | — | — | WO | disclosed |