Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071051 | 0.90 | NOTUM (0.62) | NOTUMPDE3BPDE3AKDRPDE4A | |
| SCHEMBL13071050 | 0.89 | NOTUM (0.61) | NOTUMPDE3BPDE3AKDRPDE4A | |
| SCHEMBL1769796 | 0.89 | NOTUM (0.61) | NOTUMPDE3BPDE3AKDRPDE4A | |
| SCHEMBL12649035 | 0.88 | NOTUM (0.51) | NOTUMPDE3BPDE3AKDRPDE4A | |
| SCHEMBL13071350 | 0.88 | NOTUM (0.54) | NOTUMPDE3BPDE3AKDR | |
| SCHEMBL12648793 | 0.87 | NOTUM (0.65) | NOTUMPDE3BPDE3AKDRAURKB | |
| SCHEMBL1769904 | 0.87 | PDE3B (0.55) | NOTUMPDE3BPDE3A | |
| SCHEMBL1769918 | 0.86 | PDE3B (0.59) | NOTUMPDE3BPDE3AKDRMEN1 | |
| SCHEMBL25698377 | 0.83 | NOTUM (0.47) | NOTUMPDE3BPDE3AKDR | |
| SCHEMBL12648799 | 0.83 | NOTUM (0.47) | NOTUMPDE3BPDE3AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023226950-A1 | PEPTIDOMIMETIC STAT PROTEIN DEGRADER, COMPOSITION AND USE THEREOF | 杭州和正医药有限公司 | 2023-11-30 | — | — | WO | disclosed |