Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.60 |
| ▸ | GSPT1 | P15170 | 3/20 | 0.36 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22526723 | 0.91 | DDB1 (0.62) | CRBNDDB1DRD2SLC6A4 | |
| SCHEMBL23832596 | 0.89 | CRBN (0.58) | CRBNDDB1GSPT1DRD2SLC6A4 | |
| SCHEMBL26699653 | 0.89 | DDB1 (0.56) | CRBNDDB1 | |
| SCHEMBL23842024 | 0.88 | DDB1 (0.61) | CRBNDDB1DRD2SLC6A4 | |
| SCHEMBL23833133 | 0.87 | CRBN (0.62) | CRBNDDB1GSPT1IKZF2 | |
| SCHEMBL22526820 | 0.87 | CRBN (0.62) | CRBNDDB1GSPT1IKZF2 | |
| SCHEMBL23832969 | 0.87 | CRBN (0.62) | CRBNDDB1GSPT1IKZF2 | |
| SCHEMBL22526727 | 0.87 | CRBN (0.64) | CRBNDDB1GSPT1IKZF2 | |
| SCHEMBL23832622 | 0.87 | CRBN (0.69) | CRBNDDB1 | |
| SCHEMBL23832975 | 0.86 | CRBN (0.66) | CRBNDDB1GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023226950-A1 | PEPTIDOMIMETIC STAT PROTEIN DEGRADER, COMPOSITION AND USE THEREOF | 杭州和正医药有限公司 | 2023-11-30 | — | — | WO | disclosed |
| CN-117126231-A | Peptoid STAT protein degradation agent, composition and application thereof | 杭州和正医药有限公司 | 2023-11-28 | — | — | CN | disclosed |