Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.43 |
| ▸ | ADCY6 | O43306 | 3/20 | 0.43 |
| ▸ | ADCY3 | O60266 | 3/20 | 0.43 |
| ▸ | ADCY9 | O60503 | 3/20 | 0.43 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.43 |
| ▸ | ADCY7 | P51828 | 3/20 | 0.43 |
| ▸ | ADCY2 | Q08462 | 3/20 | 0.43 |
| ▸ | ADCY1 | Q08828 | 3/20 | 0.43 |
| ▸ | ADCY4 | Q8NFM4 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2669993 | 0.92 | GCGR (0.41) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2669950 | 0.92 | GCGR (0.41) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2669951 | 0.91 | GCGR (0.45) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2669939 | 0.88 | NPC1 (0.39) | NPC1RAB9A | |
| SCHEMBL2669944 | 0.87 | GCGR (0.40) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL9070773 | 0.86 | GCG (0.42) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2669943 | 0.84 | GCGR (0.44) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL717999 | 0.82 | GCGR (0.47) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL3396953 | 0.81 | NPC1 (0.48) | GCGRNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL718691 | 0.81 | CASP3 (0.44) | GCGRADCY6ADCY3ADCY9ADCY5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251326-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009110520-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-09-11 | — | — | WO | disclosed |