SCHEMBL26706358

SCHEMBL26706358

O=C1c2cc(OC(F)(F)F)ccc2CCC1Br

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CES1 P23141 1/20 0.44
CYP19A1 P11511 1/20 0.41
GPR3 P46089 3/20 0.41
BACE1 P56817 1/20 0.39
FFAR4 Q5NUL3 4/20 0.38
FFAR1 O14842 1/20 0.38
TRPV1 Q8NER1 1/20 0.37
LRRK2 Q5S007 1/20 0.37
ACHE P22303 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26706119 0.89 CES1 (0.44) CES1CYP19A1GPR3
SCHEMBL30714800 0.81 ACHE (0.56) CYP19A1ACHE
SCHEMBL3875408 0.81 ACHE (0.56) CYP19A1ACHE
SCHEMBL26706270 0.78 PARP1 (0.51)
SCHEMBL6205297 0.77 CES1 (0.47) CES1CYP19A1GPR3BACE1LRRK2
SCHEMBL9180622 0.75 ACHE (0.51) CYP19A1ACHE
SCHEMBL31660773 0.75 PBRM1 (0.49) CES1GPR3BACE1TRPV1LRRK2
SCHEMBL8126748 0.75 PBRM1 (0.49) CES1GPR3BACE1TRPV1LRRK2
SCHEMBL9136535 0.74 CYP19A1 (0.41) CYP19A1ACHE
SCHEMBL7528414 0.74 HSD17B10 (0.52) CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4265613-A1 BENZENE RING COMPOUND AND USE THEREOF Nanjing Shijiang Medicine Technology Co., Ltd (CN) 2023-10-25 EP disclosed