Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 6/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.37 |
| ▸ | RECQL | P46063 | 4/20 | 0.37 |
| ▸ | BLM | P54132 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6372024 | 0.80 | ALDH1A1 (0.41) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL2674025 | 0.77 | KDM5B (0.42) | KDM4EALDH1A1KMT2AMEN1TDP1 | |
| SCHEMBL6372062 | 0.75 | CCNC (0.39) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL6371157 | 0.74 | KDM4E (0.40) | KDM4EALDH1A1KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL2674323 | 0.74 | CDC7 (0.38) | KDM4EALDH1A1KMT2AMEN1POLB | |
| Hydrochloric Acid SCHEMBL2674615 | 0.73 | KDM4E (0.39) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL2674592 | 0.73 | S1PR1 (0.35) | KDM4EALDH1A1BLMGAAHPGD | |
| SCHEMBL6370969 | 0.72 | TNKS (0.53) | KDM4EALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL2673942 | 0.71 | TNKS (0.52) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL6371216 | 0.71 | HTT (0.41) | KDM4EALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732896-B1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMA INC (US) | 2012-12-12 | — | — | EP | claimed |
| US-20120202795-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMACEUTICALS INC. (US) | 2012-08-09 | — | — | US | claimed |
| US-20070032489-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMACEUTICALS INC. (US) | 2007-02-08 | — | — | US | claimed |
| EP-1732896-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | Aventis Pharmaceuticals Inc. (US) | 2006-12-20 | — | — | EP | claimed |
| WO-2005097750-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMACEUTICALS INC. (US) | 2005-10-20 | — | — | WO | claimed |
| US-11130843-B2 | Methods of manufacture of polyetherimides | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2021-09-28 | — | — | US | disclosed |
| US-10457778-B2 | Methods of manufacture of polyetherimides | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2019-10-29 | — | — | US | disclosed |
| US-20180258225-A1 | METHODS OF MANUFACTURE OF POLYETHERIMIDES | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2018-09-13 | — | — | US | disclosed |
| US-20170029567-A1 | METHODS OF MANUFACTURE OF POLYETHERIMIDES | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2017-02-02 | — | — | US | disclosed |
| EP-1732896-B1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMA INC (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-1732896-B1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMA INC (US) | 2012-12-12 | — | — | EP | disclosed |
| US-20120202795-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | AVENTIS PHARMACEUTICALS INC. (US) | 2012-08-09 | — | — | US | disclosed |
| US-6590108-B1 | Transimidation of bis(imide) in presence of phthalic anhydride having substituent selected from group consisting of nitro, bromo, fluoro and chloro, to yield dianhydride | GENERAL ELECTRIC COMPANY | 2003-07-08 | — | — | US | disclosed |
| WO-2003050165-A1 | METHODS FOR THE PREPARATION OF POLY(ETHERIMIDES)S | GENERAL ELECTRIC COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |
| US-6498224-B1 | SOLUTION POLYMERIZATION OF A DIANHYDRIDE AND A DIAMINE WHICH ELIMINATES THE NITRATION STEP; HIGH HEAT ENGINEERING PLASTICS | GENERAL ELECTRIC COMPANY | 2002-12-24 | — | — | US | disclosed |
| US-6096900-A | Solventless preparation of phthalimides | GENERAL ELECTRIC COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
| US-6066743-A | Solventless preparation of phthalimides | GENERAL ELECTRIC COMPANY (US) | 2000-05-23 | — | — | US | disclosed |
| EP-0330220-B1 | Process for the preparation and recovery of oxydiphthalic anhydrides | OCCIDENTAL CHEM CO (US) | 1994-06-01 | — | — | EP | disclosed |
| US-5206391-A | Reacting BR2 with halohydrophthalic anhydride, reacting HBR with CL2 to regenerate bromine | OCCIDENTAL CHEMICAL CORPORATION (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0330220-A2 | Process for the preparation and recovery of oxydiphthalic anhydrides | OCCIDENTAL CHEMICAL CORPORATION (US) | 1989-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202795-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | PARP1, PARP2, PARP3 | KDM4E 1262/4885ALDH1A1 280/4885KMT2A 1291/4885 |
| US-20070032489-A1 | SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) | PARP1, PARP2, PARP3 | KDM4E 1262/4885ALDH1A1 280/4885KMT2A 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.