Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 18/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 17/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 13/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2674908 | 0.87 | SLC6A4 (0.65) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2675684 | 0.84 | SLC6A2 (0.53) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2675180 | 0.83 | SLC6A2 (0.53) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL952383 | 0.83 | SLC6A2 (0.60) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2676004 | 0.82 | SLC6A2 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL2675364 | 0.82 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL2675303 | 0.81 | SLC6A2 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6 | |
| SCHEMBL1058163 | 0.81 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL935263 | 0.81 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL935264 | 0.81 | SLC6A4 (0.60) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417124-B1 | Serotonin and norepinephrine reuptake inhibitor | LILLY CO ELI (US) | 2013-12-18 | — | — | EP | disclosed |
| US-8173821-B2 | Serotonin and norepinephrine reuptake inhibitor | ELI LILLY AND COMPANY (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173821-B2 | Serotonin and norepinephrine reuptake inhibitor | ELI LILLY AND COMPANY (US) | 2012-05-08 | — | — | US | disclosed |
| US-8173821-B2 | Serotonin and norepinephrine reuptake inhibitor | ELI LILLY AND COMPANY (US) | 2012-05-08 | — | — | US | disclosed |
| WO-2010117979-A2 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | ELI LILLY AND COMPANY (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20100261762-A1 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | ELI LILLY AND COMPANY (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261762-A1 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | ELI LILLY AND COMPANY (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100261762-A1 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | ELI LILLY AND COMPANY (US) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261762-A1 | SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR | SLC6A2, SLC6A4, TPH1 | SLC6A4 2/4885SLC6A2 1/4885SLC6A3 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.