Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | EYA2 | O00167 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18811750 | 0.84 | TDP1 (0.58) | ALDH1A1TDP1ALOX15TSHRCYP2C19 | |
| SCHEMBL18811744 | 0.84 | TDP1 (0.58) | ALDH1A1TDP1ALOX15TSHRCYP2C19 | |
| SCHEMBL18401328 | 0.84 | TDP1 (0.56) | ALDH1A1TDP1ALOX15TSHRCYP2C19 | |
| SCHEMBL20997750 | 0.82 | TDP1 (0.54) | TDP1ALOX15TSHRCYP2C19HRH3 | |
| SCHEMBL22766987 | 0.82 | TDP1 (0.54) | ALDH1A1TDP1ALOX15TSHRCYP2C19 | |
| SCHEMBL29319565 | 0.81 | TDP1 (0.52) | TDP1ALOX15TSHRCYP2C19HRH3 | |
| SCHEMBL14328745 | 0.80 | TDP1 (0.44) | TDP1ALOX15TSHRCYP2C19HRH3 | |
| SCHEMBL26038858 | 0.78 | TDP1 (0.45) | TDP1ALOX15TSHRCYP2C19HRH3 | |
| SCHEMBL24500053 | 0.77 | KMT2A (0.46) | ALDH1A1CYP2C19HTTKMT2A | |
| SCHEMBL17190627 | 0.77 | KMT2A (0.38) | ALDH1A1TSHRLMNABHMTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238458-A1 | COMPOUNDS TARGETING FIBROBLAST-ACTIVATION PROTEIN AND METHODS OF USE THEREOF | PURDUE RESEARCH FOUNDATION | 2024-07-18 | — | — | US | disclosed |
| US-20230364274-A1 | IMAGING AND RADIOTHERAPEUTICS AGENTS TARGETING FIBROBLAST-ACTIVATION PROTEIN-ALPHA (FAP-ALPHA) | THE JOHNS HOPKINS UNIVERSTY | 2023-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238458-A1 | COMPOUNDS TARGETING FIBROBLAST-ACTIVATION PROTEIN AND METHODS OF USE THEREOF | FAP, FIBP, FGFR1 | ALDH1A1 2246/4885TDP1 2781/4885ALOX15 2280/4885 |
| US-20230364274-A1 | IMAGING AND RADIOTHERAPEUTICS AGENTS TARGETING FIBROBLAST-ACTIVATION PROTEIN-ALPHA (FAP-ALPHA) | FAP, FIBP, FGFR1 | ALDH1A1 2789/4885TDP1 1197/4885ALOX15 4354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.