Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 3/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23323087 | 1.00 | CHRNB4 (0.50) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL23487075 | 0.84 | HTR2A (0.41) | CHRNB4CHRNA3HTR2AHTR2CHTR2B | |
| SCHEMBL13162085 | 0.83 | CHRNB4 (0.54) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL24775068 | 0.81 | HTR2A (0.40) | CHRNB4CHRNA3HTR2AHTR2CHTR2B | |
| SCHEMBL24774525 | 0.81 | HTR2A (0.40) | CHRNB4CHRNA3HTR2AHTR2CHTR2B | |
| SCHEMBL23323112 | 0.80 | CHRNB2 (0.51) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL23323111 | 0.79 | SMN1; SMN2 (0.52) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL23323074 | 0.76 | CHRNB2 (0.54) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL23323071 | 0.76 | CHRNB2 (0.54) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL23323096 | 0.74 | CHRNB2 (0.59) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023218410-A1 | METHODS OF TREATING MYELOID MALIGNANCIES USING BCL-2 INHIBITOR | BEIGENE SWITZERLAND GMBH (CH) | 2023-11-16 | — | — | WO | disclosed |